UniProtKB/Swiss-Prot P30304: Variant p.Ser88Phe

• Variant information
• Sequence information
• Literature citations
• All

Variant information

Variant position: 88 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: LB/B The variants are classified into three categories: LP/P, LB/B and US.

• LP/P: likely pathogenic or pathogenic.
• LB/B: likely benign or benign.
• US: uncertain significance

Residue change: From Serine (S) to Phenylalanine (F) at position 88 (S88F, p.Ser88Phe). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: Change from small size and polar (S) to large size and aromatic (F) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

• Lowest score: -4 (low probability of substitution).
• Highest score: 11 (high probability of substitution).

More information can be found on the following page
Other resources: Links to websites of interest for the variant.

• Variant rs3731499 [ dbSNP | Ensembl ]

Sequence information

Variant position: 88 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 524 The length of the canonical sequence.
Location on the sequence: NSNLQRMGSSESTDSGFCLD S PGPLDSKENLENPMRRIHSL The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

• Type: the type of sequence feature.
• Positions: endpoints of the sequence feature.
• Description: contains additional information about the feature.

Type	Positions	Description
Chain	1 – 524	M-phase inducer phosphatase 1
Modified residue	76 – 76	Phosphoserine; by CHEK1
Modified residue	79 – 79	Phosphoserine; by NEK11
Modified residue	82 – 82	Phosphoserine; by NEK11
Modified residue	88 – 88	Phosphoserine; by NEK11
Modified residue	107 – 107	Phosphoserine
Mutagenesis	76 – 76	S -> A. Abolishes ubiquitination and impairs CHEK1-dependent degradation following checkpoint activation.
Mutagenesis	79 – 79	S -> A. Abrogates interactions with BTRC and FBXW11 and prevents ubiquitination.
Mutagenesis	81 – 81	D -> A. Abrogates interactions with BTRC and FBXW11 and prevents ubiquitination.
Mutagenesis	82 – 82	S -> A. Abrogates interactions with BTRC and FBXW11 and prevents ubiquitination.

Literature citations

Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT PHE-88;