Variant position: 37 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 326 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VPVPSDHGGTESSPGWGSSG PWSLSPSDSSPSGVTSRLPGR
Mouse L--SSDHGGTES-----LGG LWNIN-SDSIPSGVTSRLTGR
Rat L--SPDHGGTES-----SGG LWNINSSDSIPSGVTSRLTGR
Bovine L--PSDLGETESSTSWASSG PWSLSSSDSSLPEVAARLPGR
Sheep L--PSDLGETESSTSWASSG PWSLSSSDSSLPEAAARLPGR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 326 mRNA decay activator protein ZFP36
1 – 174 Necessary for localization of ARE-containing mRNAs to processing bodies (PBs)
1 – 100 Necessary and sufficient for the association with mRNA decay enzymes and mRNA decay activation
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS SER-37; PHE-259 AND PHE-324;
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