Variant position: 259 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 326 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PLARRDPTPVCCPSCRRAT-P ISVWGPLGGLVRTPSVQSLGS
Mouse PVTRRDPNQACCPSCRRSTTP STIWGPLGGLARSPSAHSLG
Rat PVSRRDPTPACCPSCRRSTTP STIWGPLGGLARSPSAHSLG
Bovine -LCRRDPTPACCPSCRRAT-P NSVWGPVGGLARSPSAHSLG
Sheep PVSRRDPTPACCPSCRRAT-P NSVWGPVGGLARSPSAHSLG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 326 mRNA decay activator protein ZFP36
100 – 326 Necessary for localization of ARE-containing mRNAs to processing bodies (PBs)
174 – 326 Necessary for mRNA decay activation
276 – 276 Phosphoserine
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS SER-37; PHE-259 AND PHE-324;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.