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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P30519: Variant p.Pro146Leu

Heme oxygenase 2
Gene: HMOX2
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Variant information Variant position: help 146
Type of variant: help LB/B
Residue change: help From Proline (P) to Leucine (L) at position 146 (P146L, p.Pro146Leu).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help -3
Other resources: help


Sequence information Variant position: help 146
Protein sequence length: help 316
Location on the sequence: help QCPKAAQKYVERIHYIGQNE P ELLVAHAYTRYMGDLSGGQV
Residue conservation: help 
Human                         QCPKAAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQV

Mouse                         KCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQV

Rat                           KCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQV

Rabbit                        QCSEAAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQV
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 2 – 316 Heme oxygenase 2
Chain 2 – 295 Heme oxygenase 2 soluble form
Topological domain 2 – 295 Cytoplasmic
Binding site 154 – 154
Site 160 – 160 Important for catalytic activity
Helix 146 – 148



Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS GLN-137 AND LEU-146;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.