Variant position: 41 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 303 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human YKARDPHSGHFVALKSVRVP NGGGGGGGLPISTVREVALLR
Mouse YKARDPHSGHFVALKSVRVP NGGAAGGGLPVSTVREVALLR
Rat YKARDPHSGHFVALKSVRVP NGGAAGGGLPVSTVREVALLR
Pig YKARDPHSGHFVALKSVRVP NGGGAGGGLPISTVREVALLR
Bovine YKARDPHSGHFVALKSVRVP NGGGAGGGLPISTVREVALLR
Sheep YKARDPHSGHFVALKSVRVP NGGGAGGGLPISTVREVALLR
Xenopus laevis YKARDLQSGKFVALKNVRVQ T---NENGLPLSTVREVTLLK
Caenorhabditis elegans YRVRSLHDGKDYALKQIMIS S---KNEGIPQSVLREITVMK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 303 Cyclin-dependent kinase 4
6 – 295 Protein kinase
35 – 35 ATP
1 – 120 Missing. In isoform 2.
Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma.
Guldberg P.; Kirkin A.F.; Gronbaek K.; thor Straten P.; Ahrenkiel V.; Zeuthen J.;
Int. J. Cancer 72:780-783(1997)
Cited for: VARIANT CMM3 SER-41;
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