Variant position: 178 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 677 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ETD--VDLS-----------GVKFAVFGLGNKT YEHFNAMGKYVDKRLEQLGAQ
Mouse ETD--VDLT-----------GVKFAVFGLGNKT YEHFNAMG
Rat ETD--VDLT-----------GVKFAVFGLGNKT YEHFNAMG
Pig EAD--VDLT-----------GVKYAVFGLGNKT YEHFNAMG
Bovine ETD--VDLS-----------GVKYAVFALGNKT YEHFNAMG
Rabbit ETD--VDLS-----------GVKYAVFGLGNKT YEHFNAMG
Drosophila SGD--VDLS-----------GLNYAVFGLGNKT YEHYNKVA
Slime mold NDERPTDLLN----------GVPFTVFGLGNKT YEHYNAVA
Baker's yeast NAE--AGALS----------NLRYNMFGLGNST YEFFNGAA
Fission yeast GDD--TVFSSGKGIEDTPFEGIRYAIFGLGNHT YEYYNAMA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study.
Arlt W.; Walker E.A.; Draper N.; Ivison H.E.; Ride J.P.; Hammer F.; Chalder S.M.; Borucka-Mankiewicz M.; Hauffa B.P.; Malunowicz E.M.; Stewart P.M.; Shackleton C.H.L.;
Cited for: VARIANTS DISPORD ASP-178; PRO-284; HIS-454 AND TYR-566; CHARACTERIZATION OF VARIANTS DISPORD ASP-178; PRO-284; HIS-454 AND TYR-566;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.