Sequence information
Variant position: 21 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 564 The length of the canonical sequence.
Location on the sequence:
MASTSTTIRSHSSSRRGFSA
N SARLPGVSRSGFSSISVSRS
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MASTSTTIRSHSSSRRGFSAN SARLPGVSRSGFSSISVSRS
Mouse -MSTKTTIKSQT-SHRGYSAS SARVPGLNRSGFSSVSVCRS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Initiator methionine
1 – 1
Removed
Chain
2 – 564
Keratin, type II cytoskeletal 6B
Region
1 – 23
Disordered
Region
2 – 162
Head
Modified residue
2 – 2
N-acetylalanine
Literature citations
Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms.
Takahashi K.; Paladini R.D.; Coulombe P.A.;
J. Biol. Chem. 270:18581-18592(1995)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS SER-21; SER-227 AND VAL-365;
The sequence of a type II keratin gene expressed in human skin: conservation of structure among all intermediate filament genes.
Tyner A.L.; Eichman M.J.; Fuchs E.;
Proc. Natl. Acad. Sci. U.S.A. 82:4683-4687(1985)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS SER-21; SER-227 AND VAL-365;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.