Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P49427: Variant p.Asp227His

Ubiquitin-conjugating enzyme E2 R1
Gene: CDC34
Feedback?
Variant information Variant position: help 227
Type of variant: help LB/B
Residue change: help From Aspartate (D) to Histidine (H) at position 227 (D227H, p.Asp227His).
Physico-chemical properties: help Change from medium size and acidic (D) to medium size and polar (H)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 227
Protein sequence length: help 236
Location on the sequence: help YDDYYEDGEVEEEADSCFGD D EDDSGTEES
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 236 Ubiquitin-conjugating enzyme E2 R1
Region 190 – 236 SCF-binding
Region 216 – 236 Disordered
Modified residue 222 – 222 Phosphoserine; by CK2
Modified residue 231 – 231 Phosphoserine; by CK2
Modified residue 233 – 233 Phosphothreonine; by CK2
Modified residue 236 – 236 Phosphoserine; by CK2
Mutagenesis 222 – 222 S -> A. Abolishes phosphorylation by CK2. Impairs nuclear localization; when associated with A-203; A-231; A-233 and A-236.
Mutagenesis 231 – 231 S -> A. Abolishes phosphorylation by CK2. Impairs nuclear localization; when associated with A-203; A-222; A-233 and A-236.
Mutagenesis 233 – 233 T -> A. Abolishes phosphorylation by CK2. Impairs nuclear localization; when associated with A-203; A-222; A-231 and A-236.
Mutagenesis 236 – 236 S -> A. Abolishes phosphorylation by CK2. Impairs nuclear localization; when associated with A-203; A-222; A-231 and A-233.



Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT HIS-227;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.