Variant position: 808 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 862 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VLPAGDLPTHDGYLPSNIDD LPSHEAPLADSLEELEPQHIS
Mouse VTPVNYLPSHEGYLPSNIED LSPHEADPTDSFD-LEHQHIS
Pig VLPVDYLPTHEGYLPSNMDY LPSHEAPITDSLEEL-PQHIS
Bovine ILPVDYLPTHDGYLPSNMDY LPSHEAPITDPLEEL-PQHIS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
24 – 862 Interleukin-12 receptor subunit beta-2
644 – 862 Cytoplasmic
800 – 800 Phosphotyrosine
660 – 862 Missing. In isoform 2.
800 – 800 Y -> F. Loss of STAT4 activation. Abolishes SOCS3 binding.
801 – 801 L -> A. Abolishes in vitro STAT4 binding to a phosphorylated Y-800 peptide.
802 – 802 P -> A. No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide.
803 – 803 S -> A. No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide.
804 – 804 N -> A. No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide.
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS VAL-13; GLN-149; HIS-426; ASP-465 AND ARG-808;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.