Variant position: 1619 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2491 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PSKSGLSYKSVISFVCRPEA RPTNRPMLISLDKQTCTLFFS
Mouse PSLSDLRYKSVISFVCRPEA GPTNRPMLISLDKQTCTLFFS
Bovine PSKTGLSYKSVISFVCRPEV GPTNRPMLISLDKRTCTLFFS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Insulin-like growth factor II receptor as a multifunctional binding protein.
Morgan D.O.; Edman J.C.; Standring D.N.; Fried V.A.; Smith M.C.; Roth R.A.; Rutter W.J.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; PARTIAL PROTEIN SEQUENCE; VARIANT GLY-1619;
The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells.
Oshima A.; Nolan C.M.; Kyle J.W.; Grubb J.H.; Sly W.S.;
J. Biol. Chem. 263:2553-2562(1988)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT GLY-1619;
The genomic structure of the gene encoding the human mannose 6 phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R).
Gemma A.; Seike Y.; Uematsu K.; Seike M.; Bennett W.P.; Harris C.C.; Kudoh S.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT GLY-1619;
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS HIS-91; LEU-203; ASP-231; VAL-252; GLY-273; GLN-512; SER-604; THR-724; VAL-817; SER-856; MET-1107; ILE-1124; SER-1184; GLU-1315; HIS-1335; GLY-1619; HIS-1832; ASP-1860; MET-1908; SER-2020 AND VAL-2459;
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