Variant position: 296 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 580 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GYCNVVMQGCMAGVVEIDKY WREYILSLEELVNGMYRIYDM
Chimpanzee GYCNVVMQGCMAGVVEIDKY WREYILSLEELVNGMYRIYDM
Mouse GYCNVVMQGCMAGVVEIDKY WREYILSLEELVNGMYRIYDM
Rat GYCNVVMQGCMAGVVEIDKY WREYILSLEELVNGMYRIYDM
Zebrafish PLCVSTMGACLGGTTEVQPH WRAYVDELGSLAAAMKGEQDI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
25 – 358 Glypican-3 alpha subunit
197 – 349
274 – 422 Interchain (between alpha and beta chains)
278 – 410 Interchain (between alpha and beta chains)
Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene.
Veugelers M.; Cat B.D.; Muyldermans S.Y.; Reekmans G.; Delande N.; Frints S.; Legius E.; Fryns J.-P.; Schrander-Stumpel C.; Weidle B.; Magdalena N.; David G.;
Hum. Mol. Genet. 9:1321-1328(2000)
Cited for: VARIANT SGBS1 ARG-296;
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