Variant position: 68 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 700 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DPSFPAIPSALGFKELGPYS SKTRGIEWKRPTEICADPQFI
Mouse DPSFPALPSSLGYKELGPYS SKTRGIEWKRPTEICADPQFI
Rat DPSFPALPSSLGFKELGPYS SKTRGIEWKRPTEICADPQFI
Bovine DPSFPALPSSLGFKELGPYS SKTRGIEWKRPTEICDNPQFI
Chicken DPSFPAGPAALGYRELGPNS YKTKGVVWCRPTELCSCPRFI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
20 – 700 Calpain-2 catalytic subunit
45 – 344 Calpain catalytic
1 – 78 Missing. In isoform 2.
79 – 79 T -> M. In isoform 2.
60 – 68
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS GLU-22; GLY-68; ARG-476; GLN-521; GLN-568 AND GLN-677;
Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease.
Hata A.; Ohno S.; Akita Y.; Suzuki K.;
J. Biol. Chem. 264:6404-6411(1989)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79; VARIANTS GLU-22 AND GLY-68;
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