Sequence information
Variant position: 354 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
QQVKKLSLLGGALPMFELVE
L QPSHLACPDVLNLSLDSSDV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QQVKKLSLLGGALPMFELVEL QPSHLACPDVLNLSLDSSDV
Mouse QQVKKLSQLGGALPMFELVEQ QPSHLACQDVLNLSLDSSDV
Rat QQVKKLSQLGGALPMFELVEQ QPSHLACQDVLNLSLDSSDV
Bovine QQVSKLSLLGGALPMFELVEQ QPSHLACPDVLNLSLDSSDA
Chicken HQIKKLSLVRGALPMFELVER QPSHFSNPDVLNLTPDSSDA
Xenopus laevis QHIKKLSLSGGALPMFEVVDQ LPLHLSNPDVLNLTPDSSDA
Zebrafish AQIRKVSNCRG-LPMFELVDS QPSHLITADVLNLTPDFSDS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 393
Cysteine protease ATG4B
Disulfide bond
292 – 361
Disulfide bond
361 – 361
Interchain (with C-292)
Alternative sequence
321 – 354
FFCKTEDDFNDWCQQVKKLSLLGGALPMFELVEL -> KQGRLVRSLIPWAPRPSSWCAAVLGAAVVMCGTP. In isoform 3.
Alternative sequence
369 – 369
L -> LGESCQVQVGSLG. In isoform 4.
Mutagenesis
361 – 361
C -> S. Reduced formation of intrachain and interchain disulfide bonds in response to oxidation. Abolished formation of disulfide bonds, leading to increased autophagy; when associated with S-292.
Literature citations
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation.
Kabeya Y.; Mizushima N.; Yamamoto A.; Oshitani-Okamoto S.; Ohsumi Y.; Yoshimori T.;
J. Cell Sci. 117:2805-2812(2004)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION IN GABARAPL2; GABARAP AND MAP1LC3A CLEAVAGE; ACTIVE SITE; MUTAGENESIS OF CYS-74; VARIANT GLN-354;
Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Nagase T.; Ishikawa K.; Suyama M.; Kikuno R.; Hirosawa M.; Miyajima N.; Tanaka A.; Kotani H.; Nomura N.; Ohara O.;
DNA Res. 6:63-70(1999)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT GLN-354;
The full-ORF clone resource of the German cDNA consortium.
Bechtel S.; Rosenfelder H.; Duda A.; Schmidt C.P.; Ernst U.; Wellenreuther R.; Mehrle A.; Schuster C.; Bahr A.; Bloecker H.; Heubner D.; Hoerlein A.; Michel G.; Wedler H.; Koehrer K.; Ottenwaelder B.; Poustka A.; Wiemann S.; Schupp I.;
BMC Genomics 8:399-399(2007)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT GLN-354;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT GLN-354;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.