Variant position: 135 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 664 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LFVPIYIKAGVVTMPEYLRK RFGGQRIQVYLSLLSLLLYIF
Mouse IFVPIYIKAGVVTMPEYLRK RFGGKRIQIYLSVLSLLLYIF
Rat LFVPIYIKAGVVTMPEYLRK RFGGKRIQIYLSVLSLLLYIF
Rabbit VFVPIYIRAGVVTMPEYLQK RFGGKRIQIYLSILSLLLYIF
Sheep VFVPIYIKAGVVTMPEYLRK RFGGQRIQVYLSVLSLVLYIF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 664 Sodium/glucose cotransporter 1
127 – 142 Cytoplasmic
A missense mutation in the Na(+)/glucose cotransporter gene SGLT1 in a patient with congenital glucose-galactose malabsorption: normal trafficking but inactivation of the mutant protein.
Kasahara M.; Maeda M.; Hayashi S.; Mori Y.; Abe T.;
Biochim. Biophys. Acta 1536:141-147(2001)
Cited for: VARIANT GGM TRP-135;
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