Sequence information
Variant position: 387 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 435 The length of the canonical sequence.
Location on the sequence:
DTEVRSRVVGGSLRGAQAAS
P AKGEPSLPEKDEDHALSYWK
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DTEVRSRVVGGSLRGAQAASP AKGEPSLP-EKDEDHALSYWK
Mouse DTEVRRRMVGGGLQSAQASVP TEEELSSTEEEHKAHWPSHW
Rat DTEVRKRMVGGGLQSAQASVP TEEELSPTEEEQKAHRPVHW
Chicken DTEIRRRTVGENL---HVTAH KEESKSESVEEDDENMMTTW
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 435
Tyrosine-protein phosphatase non-receptor type 1
Region
378 – 398
Disordered
Modified residue
368 – 368
Phosphothreonine
Modified residue
378 – 378
Phosphoserine; by PKC
Modified residue
386 – 386
Phosphoserine; by CDK1
Literature citations
Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism.
Ukkola O.; Rankinen T.; Lakka T.; Leon A.S.; Skinner J.S.; Wilmore J.H.; Rao D.C.; Kesaeniemi Y.A.; Bouchard C.;
Obes. Res. 13:829-834(2005)
Cited for: ASSOCIATION OF VARIANT LEU-387 WITH LOW GLUCOSE TOLERANCE;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.