Sequence information
Variant position: 311 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1341 The length of the canonical sequence.
Location on the sequence:
EGQKSREAPILKEFKEEGEE
I PRVKPEEMMDERPKTRSQEQ
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EGQKSREA--PILKEFK-EEGEEI PRVKPEEMMDERP-KTRSQEQ
Mouse EAQKSREAEAPTLKQFEDEEGEER TRAKPEKVVDEKPLNIR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 1341
Apoptotic chromatin condensation inducer in the nucleus
Compositional bias
142 – 442
Glu-rich
Modified residue
295 – 295
Phosphoserine
Modified residue
326 – 326
Phosphothreonine
Modified residue
328 – 328
Phosphoserine
Cross
305 – 305
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross
315 – 315
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Alternative sequence
1 – 758
Missing. In isoform 3.
Alternative sequence
1 – 727
Missing. In isoform 2.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.