Sequence information
Variant position: 4 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 315 The length of the canonical sequence.
Location on the sequence:
MDL
R QFLMCLSLCTAFALSKPTEK
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MDLR QFLMCLSLCTAFALSKPTEK
Mouse MDLR QFLMCLSLCTAFALSKPTEK
Rat MDLR QFLMCLSLCTAFALSKPTEK
Bovine MDLR QFLMCLSLCTAFALSKPTEK
Rabbit MDLR QFLMCLSLCTAFALSKPTEK
Xenopus laevis MNKR PLLLCLGLWVACTLSKPTEK
Xenopus tropicalis MDTR RLLLCLCLWVACVVSKPTEK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Signal peptide
1 – 19
Alternative sequence
1 – 151
Missing. In isoform 15.
Alternative sequence
1 – 1
M -> MKETDLIIM. In isoform 3, isoform 4 and isoform 14.
Literature citations
Calumenin isoforms and their intracellular and extracellular function.
Wang Q.; Chen L.; Shen B.R.; Feng H.; Zheng P.L.; Teng J.L.; Chen J.G.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14 AND 15); VARIANT GLN-4;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.