Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P58004: Variant p.Thr320Ala

Sestrin-2
Gene: SESN2
Feedback?
Variant information Variant position: help 320
Type of variant: help LB/B
Residue change: help From Threonine (T) to Alanine (A) at position 320 (T320A, p.Thr320Ala).
Physico-chemical properties: help Change from medium size and polar (T) to small size and hydrophobic (A)
BLOSUM score: help 0
Other resources: help


Sequence information Variant position: help 320
Protein sequence length: help 480
Location on the sequence: help SADILEPSPHPDMLCFVEDP T FGYEDFTRRGAQAPPTFRAQ
Residue conservation: help 
Human                         SADILEPSPHPDMLCFVEDPTFGYEDFTRRGAQAPPTFRAQ

Mouse                         SADILEPSPHPDILCFVEDPAFGYEDFTRRGTQAPPTFRAQ

Bovine                        SVDILEPFANPDMLCFVEDPTFGYEDFTRRGTQAPPTFRAQ
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 480 Sestrin-2
Region 308 – 480 C-terminal domain; mediates TORC1 regulation
Mutagenesis 314 – 314 C -> S. No effect on ability to decrease intracellular reactive oxygen species.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.