Variant position: 434 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 521 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NLIPGSPLPHVGAALTVTTH P-HISIKSEPVSPSRERSPAPP
Mouse NLIPGSPLPHVGAALTVTTH P-HISIKSEPVSPSRERSPAP
Rat NLIPGSPLPHVGAALTVTTH P-HISIKSEPVSPSRERSPAP
Xenopus laevis NLVSSSHLPHT-ATLTVNTN PINISIKREPASPNRERSTGT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 521 Myocyte-specific enhancer factor 2D
439 – 439 N6-acetyllysine; alternate
444 – 444 Phosphoserine
439 – 439 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
437 – 437 S -> A. No effect on MAPK7- or EGF-mediated transcriptional activity.
438 – 438 I -> A. Abolishes K-439 sumoylation.
439 – 439 K -> R. Abolishes sumoylation and acetylation.
444 – 444 S -> A. Abolishes K-439 sumoylation. Reduced neurotoxin-induced apoptosis of neuronal cells. More resistant to degradation.
444 – 444 S -> E. No effect on K-439 sumoylation.
No reference for the current variant in UniProtKB/Swiss-Prot.
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