Variant position: 360 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 378 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GLWVPNSKASEAKEGEEA-------GP GDPLLEAVP----KTGDEKDVSV--------
Mouse GLWVPNSKSGEAKEGEEA-------GP GDPLLEAVP---
Rat GLWVPNSKSGEAKEGEEA-------GP GDPLLEAVP---
Bovine GLWVPNSKSSEAKDGEEA-------GT GDPLLEATS---
Chicken GLWVPNAKAAAEGGGQGGAHGQPGGAD SEALYEEIP---
Caenorhabditis elegans GLWVPGKADDDDDDEEAAP------AE EEPTTSS-----
Drosophila GLWVPNAADLEGDKKEEDDSDDVAGGE EKTDDAKSE---
Baker's yeast DIIGI-KAILENEKDFQSLKDQYEQDH EDATMENLSLND
Fission yeast GMLSIEEGIIDTTKGE----------- ---TIPQLS---
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 378 Hsp90 co-chaperone Cdc37
2 – 378 Hsp90 co-chaperone Cdc37, N-terminally processed
347 – 378 Disordered
377 – 377 Phosphoserine
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT GLU-360;
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