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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q00653: Variant p.Gly452Arg

Nuclear factor NF-kappa-B p100 subunit
Gene: NFKB2
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Variant information Variant position: help 452
Type of variant: help LB/B
Residue change: help From Glycine (G) to Arginine (R) at position 452 (G452R, p.Gly452Arg).
Physico-chemical properties: help Change from glycine (G) to large size and basic (R)
BLOSUM score: help -2
Other resources: help


Sequence information Variant position: help 452
Protein sequence length: help 900
Location on the sequence: help CEPQAPEMLQRAREYNARLF G LAQRSARALLDYGVTADARA
Residue conservation: help 
Human                         CEPQAPEMLQRA--------REYNARLFGLAQRSARALLDYGVTADARA

Mouse                         GEPQALDTLQRA--------REYNARLFGLAQRSARALLDY

Chicken                       CRE-----LQR---------HRHLCHLWLLARRNAHALLDY

Xenopus laevis                CSQTDSATTAQKEAQCQMIMRQANLRMLSLTQRTSRALLDY
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 900 Nuclear factor NF-kappa-B p100 subunit
Chain 1 – 454 Nuclear factor NF-kappa-B p52 subunit
Alternative sequence 429 – 900 Missing. In isoform 3.
Helix 439 – 467



Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS LYS-14; ARG-351 AND ARG-452;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.