Variant position: 11 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 290 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MAALRVLLSC VRGPLRPPVRCPAWRPFASGA
Mouse MAALRALLPR ACSSLLSSVRCPELRRFASGA
Rat MAALRALLPR ACNSLLSPVRCPEFRRFASGA
Bovine MAALRALLPR VRAPLRPWLFCPVQRSFASSA
Caenorhabditis elegans MMRFSSMLVR -NAKLCANVNQMQVAAFSSKA
Slime mold --MLKQVIKT VSSSQAP--KKYFFKQFCTST
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 27 Mitochondrion
Molecular cloning and sequence analysis of the cDNA for human mitochondrial short-chain enoyl-CoA hydratase.
Kanazawa M.; Ohtake A.; Abe H.; Yamamoto S.; Satoh Y.; Takayanagi M.; Niimi H.; Mori M.; Hashimoto T.;
Enzyme Protein 47:9-13(1993)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS ALA-11 AND ILE-75;
Human mitochondrial enoyl-CoA hydratase gene (ECHS1): structural organization and assignment to chromosome 10q26.2-q26.3.
Janssen U.; Davis E.M.; le Beau M.M.; Stoffel W.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ALA-11 AND ILE-75;
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