Variant position: 107 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 497 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SPNCRFINGFY-LENSATQST NSGIQ----NGQYKVENYLGSRDHF
Mouse SPNCRFINGFY-FENGAAQST NPGIQ----NGQYKSENCVG
Rat SPNCRFINGFY-FENGATQST SPGIQ----NGQYKSENCVG
Xenopus laevis SPNCKFINGFNNFRSDCIQTQ APVMQNSHANGFPNSAEDPG
Xenopus tropicalis SPNCKFINGFNNLRSDCILTQ VPVMQ----NGFQNSAEDLA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 497 E3 ubiquitin-protein ligase XIAP
87 – 87 Phosphoserine; by PKB
87 – 87 S -> A. No effect on dimerization.
87 – 87 S -> DE. Abolishes dimerization. Interferes with ubiquitination.
98 – 98 L -> G. Loss of interaction with TAB1/MAP3K7IP1; when associated with G-75.
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS SER-107; PHE-133; GLU-242 AND PRO-423;
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