Variant position: 501 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 770 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QAV--PPRPRHVFNMLKKYVRA EQKDRQHTLKHFEHVRMVDP----K
Chimpanzee QAV--PPRPRHVFNMLKKYVRA EQKDRQHTLKHFEHVRMVD
Mouse QAV--PPRPHHVFNMLKKYVRA EQKDRQHTLKHFEHVRMVD
Rat QAV--PPRPHHVFNMLKKYVRA EQKDRQHTLKHFEHVRMVD
Pig QAV--PPRPRHVFNMLKKYVRA EQKDRQHTLKHFEHVRMVD
Caenorhabditis elegans ATHVNKPNKHSVLQSLKAYIRA EEKDRMHTLNRYRHLLKAD
Drosophila TEQ--PPNAHHVEKCLQKLLRA LHKDRAHALAHYRHLLNSG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
18 – 770 Amyloid-beta A4 protein
18 – 687 Soluble APP-alpha
18 – 671 Soluble APP-beta
18 – 699 Extracellular
491 – 522 Heparin-binding
497 – 497 Phosphotyrosine
306 – 770 Missing. In isoform APP305.
499 – 499 R -> A. Reduced affinity for heparin; when associated with A-503.
503 – 503 K -> A. Reduced affinity for heparin; when associated with A-499.
487 – 518
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT LYS-501;
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