Variant position: 229 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 273 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LQSQMEPRTHPTWLLHIFIP FCIIAFIFIATVIALRKQLCQ
Mouse PLSRMEPKVPRTWPLHVFIP ACTIALIFLAIVIIQRKRI--
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
20 – 273 Programmed cell death 1 ligand 2
221 – 241 Helical
183 – 273 Missing. In isoform 3.
B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.
Tseng S.-Y.; Otsuji M.; Gorski K.; Huang X.; Slansky J.E.; Pai S.I.; Shalabi A.; Shin T.; Pardoll D.M.; Tsuchiya H.;
J. Exp. Med. 193:839-846(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); INDUCTION; VARIANT SER-229;
PD-L2 is a second ligand for PD-1 and inhibits T cell activation.
Latchman Y.; Wood C.R.; Chernova T.; Chaudhary D.; Borde M.; Chernova I.; Iwai Y.; Long A.J.; Brown J.A.; Nunes R.; Greenfield E.A.; Bourque K.; Boussiotis V.A.; Carter L.L.; Carreno B.M.; Malenkovich N.; Nishimura H.; Okazaki T.; Honjo T.; Sharpe A.H.; Freeman G.J.;
Nat. Immunol. 2:261-268(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); TISSUE SPECIFICITY; INDUCTION; VARIANT SER-229;
Cloning and identification of two novel splice variants of human PD-L2.
He X.-H.; Liu Y.; Xu L.-H.; Zeng Y.-Y.;
Acta Biochim. Biophys. Sin. 36:284-289(2004)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3); SUBCELLULAR LOCATION (ISOFORMS 1; 2 AND 3); VARIANT SER-229;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT SER-229;
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