Variant position: 145 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 670 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SSSQMSPLSLYGENSNSLSS AEPLKEDKPVTGPRNKTENGL
Mouse SSSQ-SPLSLYGDSCNSPSS VEPLKEEKPVTGPGNKTEHGL
Rat SSSQ-SPLSLYGDSCHSPSS AEPLKEEKPVTGPGNKTEHGL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 670 Cyclic AMP-dependent transcription factor ATF-6 alpha
1 – 377 Cytoplasmic
1 – 150 Transcription activation
Interaction of ATF6 and serum response factor.
Zhu C.; Johansen F.E.; Prywes R.;
Mol. Cell. Biol. 17:4957-4966(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS LEU-67; PRO-145 AND SER-157;
Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins; involvement of basic-leucine zipper transcription factors.
Yoshida H.; Haze K.; Yanagi H.; Yura T.; Mori K.;
J. Biol. Chem. 273:33741-33749(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS PRO-145 AND SER-157;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.