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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P18850: Variant p.Pro157Ser

Cyclic AMP-dependent transcription factor ATF-6 alpha
Gene: ATF6
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Variant information Variant position: help 157
Type of variant: help LB/B
Residue change: help From Proline (P) to Serine (S) at position 157 (P157S, p.Pro157Ser).
Physico-chemical properties: help Change from medium size and hydrophobic (P) to small size and polar (S)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 157
Protein sequence length: help 670
Location on the sequence: help ENSNSLSSAEPLKEDKPVTG P RNKTENGLTPKKKIQVNSKP
Residue conservation: help 
Human                         ENSNSLSSAEPLKEDKPVTGPRNKTENGLTPKKKIQVNSKP

Mouse                         DSCNSPSSVEPLKEEKPVTGPGNKTEHGLTPKKKIQMSSKP

Rat                           DSCHSPSSAEPLKEEKPVTGPGNKTEHGLTPKKKIQMSSKP
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 670 Cyclic AMP-dependent transcription factor ATF-6 alpha
Topological domain 1 – 377 Cytoplasmic
Region 91 – 183 Disordered
Cross 152 – 152 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Mutagenesis 152 – 152 K -> R. Almost complete loss of RNF186-mediated ubiquitination.



Literature citations
Interaction of ATF6 and serum response factor.
Zhu C.; Johansen F.E.; Prywes R.;
Mol. Cell. Biol. 17:4957-4966(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; TISSUE SPECIFICITY; VARIANTS LEU-67; PRO-145 AND SER-157; Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins; involvement of basic-leucine zipper transcription factors.
Yoshida H.; Haze K.; Yanagi H.; Yura T.; Mori K.;
J. Biol. Chem. 273:33741-33749(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS PRO-145 AND SER-157;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.