Variant position: 268 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 362 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MQE---APESATVIFAGDTNLRD REVTRCGGLPNNIVDVWEFLG
Mouse MQE---APDSTTVIFAGDTNLRD QEVIKCGGLPDNVFDAWE
Rat MQE---ATDSTTVIFAGDTNLRD QEVIKCGGLPDNVFDAWE
Bovine MQE---APGSATVIFAGDTNLRD QEVTKCGGLPNNILDVWE
Chicken MQE---ESQSTTVIFGGDTNLRD SEVAKLGGLPKNITDIWE
Xenopus laevis MMD---APPSATVIFGGDTNLRD QEVAKIGGLPNTILDVWE
Xenopus tropicalis MMD---APPLATVIFGGDTNLRD QEVAKIGGMPNNILDVWD
Zebrafish IKE---APEDAIVIFAGDTNLRD AEVANVGGLPAGVCDVWE
Caenorhabditis elegans VREIIAQNPGALVFFGGDLNLRD EEVSRV---PDGVKDAWE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 362 Tyrosyl-DNA phosphodiesterase 2
262 – 262 Proton donor/acceptor
262 – 262 D -> A. Loss of phosphodiesterase activity.
262 – 262 D -> HLM. Loss of phosphodiesterase activity.
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS GLU-249 AND GLN-268;
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