Variant position: 163 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 934 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ASIGVVGVKMSAV-DGQRQVG VGYVDSIQRKLGLCEFPDNDQ
Mouse ASVGVMGIKMAVV-DGQRHVG VGYVDSTQRKLGLCEFPEND
Rat TSIGIMGIKLSTV-DGQRQVG VGDVDSTQRKLGLCEFPDND
Bovine ASIGVVGVKMSTV-DGQRQVG VGYVDSTQRKLGLCEFPDND
Drosophila VGNSIISLLVKLDGGGQRRVG VASVEQNDCKFQLLEFLDDD
Slime mold EGSVMMALKVTRE-KGSIVFG ISFGDATFKTIGVSQFMDND
Baker's yeast IIIASLKVQWNSQ-DGNCIIG VAFIDTTAYKVGMLDIVDNE
Fission yeast VSSVLLAVTTRVK-QDQRIIG VAFIDPILKKLGVSEFVDSD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 934 DNA mismatch repair protein Msh2
160 – 167
Genomic deletions in MSH2 or MLH1 are a frequent cause of hereditary non-polyposis colorectal cancer: identification of novel and recurrent deletions by MLPA.
Taylor C.F.; Charlton R.S.; Burn J.; Sheridan E.; Taylor G.R.;
Hum. Mutat. 22:428-433(2003)
Cited for: VARIANTS HNPCC1 GLY-163 AND GLY-660;
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