Variant position: 257 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 288 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LSSYWSQHLGKKEMHAFQCS HRGGELGISLRPDGRVDIRGG
Rat LSSYWSQQLGKKEMRAFQCS CRGGELDISLRPDGRVDMKGG
Bovine LSSYWSEQLGKKDLHAFQCS NRGGELTISLRSDGRVDIKGG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 288 Phenazine biosynthesis-like domain-containing protein
252 – 288 AFQCSHRGGELGISLRPDGRVDIRGGAAVVLEGTLTA -> GRTALYQFLFYLPNSKLVFLLICTIPLKM. In isoform 2.
Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family.
van Dijk M.; Mulders J.; Poutsma A.; Koenst A.A.M.; Lachmeijer A.M.A.; Dekker G.A.; Blankenstein M.A.; Oudejans C.B.M.;
Nat. Genet. 37:514-519(2005)
Cited for: VARIANTS CYS-17 AND ARG-257;
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