Variant position: 388 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 505 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LISEGQGFMTREFLKSLRKP FGDFMEPKFEFAVKFNALELD
Rhesus macaque LISEGQGFMTREFLKSLRKP FGDFMEPKFEFAVKFNALELD
Mouse LISEGQGFMTREFLKNLRKP FGDFMEPKFEFAVKFNALELD
Rat LISEGQGFMTREFLKSLRKP FGDFMEPKFEFAVKFNALELD
Pig LISEGQGFMTREFLKSLRKP FGDFMEPKFEFAVKFNALELD
Bovine LISEGQGFMTREFLKSLRKP FGDFMEPKFEFAVKFNALELD
Rabbit LISEGQGFMTREFLKSLRKP FGDFMEPKFEFAVKFNALELD
Xenopus laevis LVAEGQGFMTREFLKSLRKP FSDFMEPKFEFAIRFNSLELD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 505 Peroxisome proliferator-activated receptor gamma
238 – 503 NR LBD
214 – 504 Missing. In isoform 3.
388 – 390
PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy.
Hegele R.A.; Cao H.; Frankowski C.; Mathews S.T.; Leff T.;
Cited for: VARIANT FPLD3 LEU-388;
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