Variant position: 425 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 505 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LELDDSDLAIFIAVIILSGD RPGLLNVKPIEDIQDNLLQAL
Rhesus macaque LELDDSDLAIFIAVIILSGD RPGLLNVKPIEDIQDNLLQAL
Mouse LELDDSDLAIFIAVIILSGD RPGLLNVKPIEDIQDNLLQAL
Rat LELDDSDLAIFIAVIILSGD RPGLLNVKPIEDIQDNLLQAL
Pig LELDDSDLAIFIAVIILSGD RPGLLNVKPIEDIQDNLLQAL
Bovine LELDDSDLAIFIAVIILSGD RPGLLNVKPIEDIQDNLLQAL
Rabbit LELDDSDLAIFIAVIILSGD RPGLLNVKPIEDIQDNLLQAL
Xenopus laevis LELDDSDLAIFVAVIILSGD RPGLLNVKPIEDIQDSLLQAL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 505 Peroxisome proliferator-activated receptor gamma
238 – 503 NR LBD
214 – 504 Missing. In isoform 3.
423 – 425
A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy.
Agarwal A.K.; Garg A.;
J. Clin. Endocrinol. Metab. 87:408-411(2002)
Cited for: VARIANT FPLD3 CYS-425;
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