Variant position: 166 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 655 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LRLATTMTNHEKNERINRVI QELGLDKVADSKVGTQFIRGV
Rhesus macaque LRLPTTMTNHEKNERINRVI QELGLDKVADSKVGTQFIRGV
Mouse LRLPTTMKNHEKNERINTII KELGLEKVADSKVGTQFIRGI
Rat LRLPKAMKTHEKNERINTII KELGLDKVADSKVGTQFTRGI
Pig LRLPTTMTNHEKNERINMVI QELGLDKVADSKVGTQFIRGV
Bovine LRLPTTMTSYEKNERINKVI QELGLDKVADSKVGTQFIRGV
Slime mold LQMSEGTSEEEKNARVDYIL KTLDLTRQQDTVVGNEFLRGV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 655 Broad substrate specificity ATP-binding cassette transporter ABCG2
1 – 395 Cytoplasmic
37 – 286 ABC transporter
154 – 168
A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.
Allikmets R.; Schriml L.M.; Hutchinson A.; Romano-Spica V.; Dean M.;
Cancer Res. 58:5337-5339(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS GLU-166 AND SER-208; TISSUE SPECIFICITY;
The expression and functional characterization of ABCG2 in brain endothelial cells and vessels.
Zhang W.; Mojsilovic-Petrovic J.; Andrade M.F.; Zhang H.; Ball M.; Stanimirovic D.B.;
FASEB J. 17:2085-2087(2003)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; CATALYTIC ACTIVITY; TISSUE SPECIFICITY; VARIANTS GLU-166 AND SER-208;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.