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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P30154: Variant p.Val498Glu

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Gene: PPP2R1B
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Variant information Variant position: help 498 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help US The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Valine (V) to Glutamate (E) at position 498 (V498E, p.Val498Glu). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and hydrophobic (V) to medium size and acidic (E) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In a colorectal cancer patient. Any additional useful information about the variant.


Sequence information Variant position: help 498 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 601 The length of the canonical sequence.
Location on the sequence: help LMKLVQKFGTEWAQNTIVPK V LVMANDPNYLHRMTTLFCIN The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         LMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCIN

Mouse                         LMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCIN

Rat                           LMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCIN

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 2 – 601 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Repeat 490 – 528 HEAT 13



Literature citations
Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers.
Takagi Y.; Futamura M.; Yamaguchi K.; Aoki S.; Takahashi T.; Saji S.;
Gut 47:268-271(2000)
Cited for: VARIANTS ALA-15; PRO-365; GLU-498; ILE-499 AND GLY-500;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.