Variant position: 499 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 601 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MKLVQKFGTEWAQNTIVPKV LVMANDPNYLHRMTTLFCINA
Mouse MKLVQKFGTEWAQNTIVPKV LVMANDPNYLHRMTTLFCINA
Rat MKLVQKFGTEWAQNTIVPKV LVMANDPNYLHRMTTLFCINA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 601 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
490 – 528 HEAT 13
Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers.
Takagi Y.; Futamura M.; Yamaguchi K.; Aoki S.; Takahashi T.; Saji S.;
Cited for: VARIANTS ALA-15; PRO-365; GLU-498; ILE-499 AND GLY-500;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.