Variant position: 26 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 805 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human WLLLSLVAVTAAQSTIEEQA KTFLDKFNHEAEDLFYQSSLA
Mouse WLLLSLVAVTTAQSLTEENA KTFLNNFNQEAEDLSYQSSLA
Rat WLLLSLVAVATAQSLIEEKA ESFLNKFNQEAEDLSYQSSLA
Bovine WLLLSLVAVTAAQSTTEEQA KTFLEKFNHEAEDLSYQSSLA
Cat WLLLSFAALTAAQSTTEELA KTFLEKFNHEAEELSYQSSLA
Baker's yeast WYI---NPSGFAKDTQDEEY VQHHDN----------VNPTI
Fission yeast ------MSLSYLSSSSQKSF ESFRQE----------ESPAC
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
18 – 805 Angiotensin-converting enzyme 2
18 – 708 Processed angiotensin-converting enzyme 2
18 – 740 Extracellular
24 – 26 QAK -> KAE. Slightly inhibits interaction with SARS-CoV spike glycoprotein.
31 – 31 K -> D. Abolishes interaction with SARS-CoV spike glycoprotein.
37 – 37 E -> A. No effect on interaction with SARS-CoV spike glycoprotein.
38 – 38 D -> A. No effect on interaction with SARS-CoV spike glycoprotein.
41 – 41 Y -> A. Strongly inhibits interaction with SARS-CoV spike glycoprotein.
23 – 52
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT ARG-26;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.