Variant position: 638 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 805 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IKVRISLKSALGDKAYE--WND- NEMYLFRSSVAYAMRQYFLKV
Mouse IKVRISLKSALGANAYE--WTN- NEMFLFRSSVAYAMRKYF
Rat IKVRISLKSALGKNAYE--WTD- NEMYLFRSSVAYAMREYF
Bovine IKVRISLKSALGENAYE--WND- NEMYLFQSSVAYAMRKYF
Cat IKVRISLKSALGDEAYE--WND- NEMYLFRSSVAYAMREYF
Baker's yeast ----------LPDKLFECLYPNC NKVFKRRYNIRSHIQTHL
Fission yeast ----------EADGKYVCLYNGC NKRIARKYNVESHIQTHL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
18 – 805 Angiotensin-converting enzyme 2
18 – 708 Processed angiotensin-converting enzyme 2
18 – 740 Extracellular
556 – 805 Missing. In isoform 2.
637 – 657
Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population.
Itoyama S.; Keicho N.; Hijikata M.; Quy T.; Phi N.C.; Long H.T.; Ha L.D.; Ban V.V.; Matsushita I.; Yanai H.; Kirikae F.; Kirikae T.; Kuratsuji T.; Sasazuki T.;
Am. J. Med. Genet. A 136:52-57(2005)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT SER-638;
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