UniProtKB/SwissProt variant VAR

Variant information

Variant position:

638

The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:

LB/B

The variants are classified into three categories: LP/P, LB/B and US.

LP/P: likely pathogenic or pathogenic.
LB/B: likely benign or benign.
US: uncertain significance

Residue change:

From Asparagine (N) to Serine (S) at position 638 (N638S, p.Asn638Ser).

Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:

Change from medium size and polar (N) to small size and polar (S)

The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:

1

The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

Lowest score: -4 (low probability of substitution).
Highest score: 11 (high probability of substitution).

More information can be found on the following page

Other resources:

Links to websites of interest for the variant.

Variant rs183135788 [ dbSNP | Ensembl ]

Sequence information

Variant position:

638

The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:

805

The length of the canonical sequence.

Location on the sequence:

IKVRISLKSALGDKAYEWND N EMYLFRSSVAYAMRQYFLKV

The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation:

The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         IKVRISLKSALGDKAYE--WND-NEMYLFRSSVAYAMRQYFLKV

Mouse                         IKVRISLKSALGANAYE--WTN-NEMFLFRSSVAYAMRKYF

Rat                           IKVRISLKSALGKNAYE--WTD-NEMYLFRSSVAYAMREYF

Bovine                        IKVRISLKSALGENAYE--WND-NEMYLFQSSVAYAMRKYF

Cat                           IKVRISLKSALGDEAYE--WND-NEMYLFRSSVAYAMREYF

Baker's yeast                 ----------LPDKLFECLYPNCNKVFKRRYNIRSHIQTHL

Fission yeast                 ----------EADGKYVCLYNGCNKRIARKYNVESHIQTHL

Sequence annotation in neighborhood:

The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

Type: the type of sequence feature.
Positions: endpoints of the sequence feature.
Description: contains additional information about the feature.

Type	Positions	Description
Chain	18 – 805	Angiotensin-converting enzyme 2
Chain	18 – 708	Processed angiotensin-converting enzyme 2
Topological domain	18 – 740	Extracellular
Helix	637 – 657

Literature citations

Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population.
Itoyama S.; Keicho N.; Hijikata M.; Quy T.; Phi N.C.; Long H.T.; Ha L.D.; Ban V.V.; Matsushita I.; Yanai H.; Kirikae F.; Kirikae T.; Kuratsuji T.; Sasazuki T.;
Am. J. Med. Genet. A 136:52-57(2005)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT SER-638;

Genetic variability of human angiotensin-converting enzyme 2 (hACE2) among various ethnic populations.
Li Q.; Cao Z.; Rahman P.;
Mol. Genet. Genomic Med. 0:0-0(2020)
Cited for: VARIANTS ARG-26; VAL-468; SER-638 AND ASP-720;

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q9BYF1: Variant p.Asn638Ser