Variant position: 163 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 346 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LLLDENGVLKLADFGLAKSF GSPNRAYTHQVVTRWYRAPEL
Mouse LLLDENGVLKLADFGLAKSF GSPNRAYTHQVVTRWYRAPEL
Xenopus laevis LLLDENGVLKLADFGLAKSF GSPNRIYTHQVVTRWYRSPEL
Caenorhabditis elegans LLMNKMGRVKLTDFGLARFF GSPNRNYTHQVVTRWYRAPEL
Slime mold LLMSINGDLKLADFGLARQY GSPNKVFSPQAVTIFYRAPEL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 346 Cyclin-dependent kinase 7
12 – 295 Protein kinase
164 – 164 Phosphoserine; by CDK1 and CDK2
170 – 170 Phosphothreonine; by CDK2
164 – 164 S -> A. No mitotic repression of transcriptional activity of the reconstituted TFIIH complex.
170 – 170 T -> A. Total loss of activity. Total loss of transcriptional activity of the reconstituted TFIIH complex.
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ALA-163 AND MET-285;
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