UniProtKB/SwissProt variant VAR

Variant information

Variant position:

45

The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:

LB/B

The variants are classified into three categories: LP/P, LB/B and US.

LP/P: likely pathogenic or pathogenic.
LB/B: likely benign or benign.
US: uncertain significance

Residue change:

From Glycine (G) to Aspartate (D) at position 45 (G45D, p.Gly45Asp).

Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:

Change from glycine (G) to medium size and acidic (D)

The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:

-1

The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

Lowest score: -4 (low probability of substitution).
Highest score: 11 (high probability of substitution).

More information can be found on the following page

Other resources:

Links to websites of interest for the variant.

Variant rs4646422 [ dbSNP | Ensembl ]

Sequence information

Variant position:

45

The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:

512

The length of the canonical sequence.

Location on the sequence:

VIRASRPQVPKGLKNPPGPW G WPLIGHMLTLGKNPHLALSR

The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation:

The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         VIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSR

                              VVKAWQPRLPKGLKSPPGPWGWPVLGNVLTLGKSPHLALSR

Rhesus macaque                VIRASRPRVPKGLKNPPGPWGWPLIGHILTLGKNPHLALSR

Mouse                         VVRATRTWVPKGLKTPPGPWGLPFIGHMLTVGKNPHLSLTR

Rat                           VVRVTRTWVPKGLKSPPGPWGLPFIGHVLTLGKNPHLSLTK

Rabbit                        VAGASKPRVPKGLKRLPGPWGWPLLGHVLTLGKNPHVALAR

Sheep                         VVRTWRPRVPQGLKSPPEPWGWPCLGHVLTLGKNPHVVLSQ

Cat                           VVRAWQPRVPKGLKSPPGPWGWPLLGHVLTLGKNPHLVLAR

Sequence annotation in neighborhood:

The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

Type: the type of sequence feature.
Positions: endpoints of the sequence feature.
Description: contains additional information about the feature.

Type	Positions	Description
Chain	1 – 512	Cytochrome P450 1A1
Alternative sequence	1 – 261	Missing. In isoform 3.

Literature citations

Submission
Suzuki Y.; Sugano S.; Totoki Y.; Toyoda A.; Takeda T.; Sakaki Y.; Tanaka A.; Yokoyama S.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT ASP-45;

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.
Solus J.F.; Arietta B.J.; Harris J.R.; Sexton D.P.; Steward J.Q.; McMunn C.; Ihrie P.; Mehall J.M.; Edwards T.L.; Dawson E.P.;
Pharmacogenomics 5:895-931(2004)
Cited for: VARIANTS ASP-45; THR-78; TRP-93; ARG-173; ASN-461; MET-482 AND ARG-492;

Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
Jiang Z.; Dalton T.P.; Jin L.; Wang B.; Tsuneoka Y.; Shertzer H.G.; Deka R.; Nebert D.W.;
Hum. Mutat. 25:196-206(2005)
Cited for: VARIANTS ASP-45; THR-78; ASN-461 AND VAL-462;

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04798: Variant p.Gly45Asp