Variant position: 18 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 516 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MALSQSVPFSATELLLA SAIFCLVFWVLKGLRPRVPKG
Mouse MAFSQYIS-LAPELLLA TAIFCLVFWMVRASRTQVPKG
Rat MAFSQYIS-LAPELLLA TAIFCLVFWVLRGTRTQVPKG
Rabbit MAMSPAAPLSVTELLLV SAVFCLVFWAVRASRPKVPKG
Cat MAISP----TATELLLA SFAFCLVFWVVRAWQPRVPKG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1 Removed
2 – 516 Cytochrome P450 1A2
Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.
Solus J.F.; Arietta B.J.; Harris J.R.; Sexton D.P.; Steward J.Q.; McMunn C.; Ihrie P.; Mehall J.M.; Edwards T.L.; Dawson E.P.;
Cited for: VARIANTS CYS-18; ARG-298; VAL-314 AND TRP-431;
Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
Jiang Z.; Dalton T.P.; Jin L.; Wang B.; Tsuneoka Y.; Shertzer H.G.; Deka R.; Nebert D.W.;
Hum. Mutat. 25:196-206(2005)
Cited for: VARIANT CYS-18;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.