Sequence information
Variant position: 363 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 502 The length of the canonical sequence.
Location on the sequence:
KSPGPIVSRTRSWDSSSPVD
R PEPEAASPTTRTRPVTRSMG
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KSPGPIVSRTRSWDSSSPVDR PEPEAASPTTRTRPVTRSMG
Mouse KSPGPIVSRTRSWESSSPVDR PELEAASPTTRSRPVTRSMG
Xenopus laevis QSPAFAYGRTRSSDLLSPAD- ------SEAVRNRPVTRSMG
Xenopus tropicalis QSPALAYGRTRSSDLLSPAD- ------SEAVRSRPVTRSMG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 502
Nuclear-interacting partner of ALK
Modified residue
344 – 344
Phosphoserine
Modified residue
354 – 354
Phosphoserine
Modified residue
359 – 359
Phosphoserine
Modified residue
370 – 370
Phosphoserine
Modified residue
381 – 381
Phosphoserine
Alternative sequence
341 – 411
Missing. In isoform 3.
Mutagenesis
354 – 354
S -> A. Strongly reduces phosphorylation and induces the formation of a constitutive SCF(NIPA) E3 complex that degrades CCNB1 at G2/M phase and delays mitotic entry.
Literature citations
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANTS ALA-271 AND HIS-363;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.