Variant position: 363 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 502 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KSPGPIVSRTRSWDSSSPVD RPEPEAASPTTRTRPVTRSMG
Mouse KSPGPIVSRTRSWESSSPVD RPELEAASPTTRSRPVTRSMG
Xenopus laevis QSPAFAYGRTRSSDLLSPAD -------SEAVRNRPVTRSMG
Xenopus tropicalis QSPALAYGRTRSSDLLSPAD -------SEAVRSRPVTRSMG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 502 Nuclear-interacting partner of ALK
344 – 344 Phosphoserine
354 – 354 Phosphoserine
359 – 359 Phosphoserine
370 – 370 Phosphoserine
381 – 381 Phosphoserine
341 – 411 Missing. In isoform 3.
354 – 354 S -> A. Strongly reduces phosphorylation and induces the formation of a constitutive SCF(NIPA) E3 complex that degrades CCNB1 at G2/M phase and delays mitotic entry.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANTS ALA-271 AND HIS-363;
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