Variant position: 671 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 717 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DRKRRDTSGLERSHKSSKGG SSRDTKGSKDKNSRSDRKRSI
Mouse DRKRRDTSGLERSHKSSKGG SSRDRKGSKDKSSRPDRKRSI
Bovine DRKRRDASGLERSHKSAKGG SSRDAK-------------AV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 717 Pinin
279 – 717 Disordered
606 – 717 Necessary for interaction with PPIG
653 – 717 Basic and acidic residues
658 – 658 Phosphoserine
Totoki Y.; Toyoda A.; Takeda T.; Sakaki Y.; Tanaka A.; Yokoyama S.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT GLY-671;
memA/DRS, a putative mediator of multiprotein complexes, is overexpressed in the metastasizing human melanoma cell lines BLM and MV3.
Degen W.G.J.; Agterbos M.A.; Muyrers J.P.P.; Bloemers H.P.J.; Swart G.W.M.;
Biochim. Biophys. Acta 1444:384-394(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-717; VARIANT GLY-671; TISSUE SPECIFICITY;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.