Variant position: 39 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 503 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EAMPAATMPVLLLTGLFLLV WNYEGTSSIPGPGYCMGIGPL
Mouse ETVTVSAMPLLLIMGLLLLI WNCESSSSIPGPGYCLGIGPL
Rat ETVPVSAMPLLLIMGLLLLI RNCESSSSIPGPGYCLGIGPL
Bovine EVVPIASIAILLLTGFLLLV WNYEDTSSIPGPSYFLGIGPL
Rabbit AAMPAATMPILLLTCLLLLI WNYEGTSSIPGPGYCMGIGPL
Goat EVVPIASIAILLLTGFLLLV WNYEDTSSIPGPSYFLGIGPL
Sheep EVVPIASIAILLLTGFLLLV WNYEDTSSIPGPSYFLGIGPL
Horse EVMPVATLPILLLTGFLFFV WNHEETSSIPGPGYCMGIGPL
Chicken DLMPVATVPIIILICFLFLI WNHEETSSIPGPGYCMGIGPL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 503 Aromatase
19 – 39 Helical
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ARG-39; MET-201 AND CYS-264;
Breast cancer risk associated with polymorphism in CYP19 in Japanese women.
Miyoshi Y.; Iwao K.; Ikeda N.; Egawa C.; Noguchi S.;
Int. J. Cancer 89:325-328(2000)
Cited for: VARIANTS ARG-39 AND CYS-264;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.