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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P30304: Variant p.Arg182Gly

M-phase inducer phosphatase 1
Gene: CDC25A
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Variant information Variant position: help 182
Type of variant: help LB/B
Residue change: help From Arginine (R) to Glycine (G) at position 182 (R182G, p.Arg182Gly).
Physico-chemical properties: help Change from large size and basic (R) to glycine (G)
BLOSUM score: help -2
Other resources: help


Sequence information Variant position: help 182
Protein sequence length: help 524
Location on the sequence: help SHGLQEGKDLFTQRQNSAPA R MLSSNERDSSEPGNFIPLFT
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 524 M-phase inducer phosphatase 1
Modified residue 178 – 178 Phosphoserine; by CHEK1
Alternative sequence 144 – 183 Missing. In isoform 2.
Mutagenesis 178 – 178 S -> A. Increases basal stability and impairs CHEK1-dependent degradation following checkpoint activation; when associated with A-124; A-279 and A-293. Abrogates 14-3-3 protein binding.



Literature citations
Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins.
Galaktionov K.I.; Beach D.;
Cell 67:1181-1194(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; ACTIVITY REGULATION; VARIANT GLY-182;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.