Variant position: 45 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 200 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GDEVNVEEVQAIMEAYESDP TEWAMYAKFDQYRYTRNLVDQ
Mouse GDEVNVEEVQAVLEAYESNP AEWALYAKFDQYRYTRNLVDQ
Rat GDEVNVEEVQAVLEAYESNP AEWALYAKFDQYRYTRNLVDQ
Bovine GEEINVEEVQAVMEAYESNP AEWAVYAKFDQYRYTRNLVDQ
Zebrafish SDSINVEEVQNLMESYQSNP QDWMKFAKFDQYRYTRNLVDE
Caenorhabditis elegans QKLIDVDEVMKLMASYKSNA NEWRRFAIFDMNKYTRNLVDV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 200 Cysteine dioxygenase type 1
60 – 60 R -> Q. Reduces enzyme activity by 70%. Reduces iron and zinc incorporation by 50%.
44 – 47
Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA.
McCann K.P.; Akbari M.T.; Williams A.C.; Ramsden D.B.;
Biochim. Biophys. Acta 1209:107-110(1994)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT ILE-45;
Human cysteine dioxygenase type I (CDO-I; EC 188.8.131.52): 5' flanking region and intron-exon structure of the gene.
Ramsden D.B.; Kapadi A.L.; Fitch N.J.; Farmer M.J.; Bennett P.; Williams A.C.;
Mol. Pathol. 50:269-271(1997)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT ILE-45;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.