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UniProtKB/Swiss-Prot Q9BUP3: Variant p.Ser197Arg

Oxidoreductase HTATIP2
Gene: HTATIP2
Variant information

Variant position:  197
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Serine (S) to Arginine (R) at position 197 (S197R, p.Ser197Arg).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from small size and polar (S) to large size and basic (R)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  Highly associated with hepatocellular carcinoma (HCC) progression.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  197
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  242
The length of the canonical sequence.

Location on the sequence:   SRPGEWLVRKFFGSLPDSWA  S GHSVPVVTVVRAMLNNVVRP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         SRPGEWLVRKFFGSLPDSWASGHSVPVVTVVRAMLNNVVRP

Gorilla                       SRPGEWLVRKFFGSLPESWASGHSVPVVTVVRAMLNNVVRP

Mouse                         SRPGEWLARKFFGSLPDSWASGYAVPVVTVVRAMLNNLVSP

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 2 – 242 Oxidoreductase HTATIP2
Alternative sequence 134 – 242 Missing. In isoform 2.
Helix 195 – 198


Literature citations

A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma.
Shtivelman E.;
Oncogene 14:2167-2173(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; TISSUE SPECIFICITY; VARIANT ARG-197;

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3); VARIANT ARG-197;

Initial characterization of the human central proteome.
Burkard T.R.; Planyavsky M.; Kaupe I.; Breitwieser F.P.; Buerckstuemmer T.; Bennett K.L.; Superti-Furga G.; Colinge J.;
BMC Syst. Biol. 5:17-17(2011)
Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-197; IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];

Large-scale quantification of single amino-acid variations by a variation-associated database search strategy.
Song C.; Wang F.; Cheng K.; Wei X.; Bian Y.; Wang K.; Tan Y.; Wang H.; Ye M.; Zou H.;
J. Proteome Res. 13:241-248(2014)
Cited for: VARIANT ARG-197;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.