Variant position: 551 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 728 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SLFVAFQLRAQHFQ--ENSRMP VIKPDIANWELSVKL------HDKVHT
Mouse SVFVASQLRAQRFQ--EHSRVP VIRPDVAKWELSVKL----
Rat SLFVASQLRAQRFQ--EHSRVP VIRPDVAKWELSVKL----
Pig SLFVASQLRAQRFQEPENSRVP IIKPQVANWELSIRL----
Caenorhabditis elegans ALNARKLARANQFLNQNKQRST HVASFSKTYKFVSSLPVKE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
53 – 728 Propionyl-CoA carboxylase alpha chain, mitochondrial
Propionic acidemia: identification of twenty-four novel mutations in Europe and North America.
Perez B.; Desviat L.R.; Rodriguez-Pombo P.; Clavero S.; Navarrete R.; Perez-Cerda C.; Ugarte M.;
Mol. Genet. Metab. 78:59-67(2003)
Cited for: VARIANT PHE-551; VARIANT PA-1 LEU-532 DEL;
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