Sequence information
Variant position: 233 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 424 The length of the canonical sequence.
Location on the sequence:
AQAPLPGGPRASVFDLKAIA
S LLRLPDVPRIFLVKVASNCP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AQAPLPGGPRASVFDLKAIAS LLRLPDVPRIFLVKVASNCP
Mouse VQSAPQGGTKASVFDLKAITR LLLLPRVLPVFLVKVISGLP
Rat VQSAHQGGT--SVFDLKAISR LLLLPRVLPVFLVKVISGFP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 424
Solute carrier family 22 member 18
Literature citations
Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5.
Lee M.P.; Reeves C.; Schmitt A.; Su K.; Connors T.D.; Hu R.J.; Brandenburg S.; Lee M.J.; Miller G.; Feinberg A.P.;
Cancer Res. 58:4155-4159(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT GLN-309; VARIANT LUNG CANCER PHE-233;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.