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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P21918: Variant p.Val238Ile

D(1B) dopamine receptor
Gene: DRD5
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Variant information Variant position: help 238
Type of variant: help LB/B
Residue change: help From Valine (V) to Isoleucine (I) at position 238 (V238I, p.Val238Ile).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help 3
Other resources: help


Sequence information Variant position: help 238
Protein sequence length: help 477
Location on the sequence: help DSSLNRTYAISSSLISFYIP V AIMIVTYTRIYRIAQVQIRR
Residue conservation: help 
Human                         DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR

Mouse                         DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR

Rat                           DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR

Xenopus laevis                DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQIKR
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 477 D(1B) dopamine receptor
Transmembrane 224 – 246 Helical; Name=5
Glycosylation 222 – 222 N-linked (GlcNAc...) asparagine
Helix 235 – 270



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.