Variant position: 52 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 389 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RSCQNLG----------------------YTAASPQAPEAAS NTGNAERAEEVPGEGSLFLQA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 389 SH2 domain-containing protein 2A
Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites.
Spurkland A.; Brinchmann J.E.; Markussen G.; Pedeutour F.; Munthe E.; Lea T.; Vartdal F.; Aasheim H.-C.;
J. Biol. Chem. 273:4539-4546(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3); VARIANT SER-52;
The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1.
Dai K.Z.; Vergnaud G.; Ando A.; Inoko H.; Spurkland A.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4); ALTERNATIVE SPLICING; VARIANT SER-52;
VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor.
Wu L.-W.; Mayo L.D.; Dunbar J.D.; Kessler K.M.; Ozes O.N.; Warren R.S.; Donner D.B.;
J. Biol. Chem. 275:6059-6062(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); INTERACTION WITH KDR; VARIANT SER-52;
Lee J.-S.; Suh K.S.; Burr J.G.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3); VARIANT SER-52;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2); VARIANT SER-52;
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Rush J.; Moritz A.; Lee K.A.; Guo A.; Goss V.L.; Spek E.J.; Zhang H.; Zha X.-M.; Polakiewicz R.D.; Comb M.J.;
Nat. Biotechnol. 23:94-101(2005)
Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-52; IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];
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